French fold out paper doll depicting the human body and its internal organs, printed circa 1910.
Paper dolls for med students!
French fold out paper doll depicting the human body and its internal organs, printed circa 1910.
Paper dolls for med students!
Detecting brain cancer without surgery
Currently, there is no way to accurately diagnose the presence of a brain tumor without actually cutting into the skull. Nor is there a reliable method for monitoring the progression of brain cancer. But in a paper, published online this week in the journal Neuro-Oncology, Santosh Kesari, MD, PhD, director of Neuro-Oncology at UC San Diego Moores Cancer Center, with colleagues at the Brigham and Women’s Hospital and elsewhere describe a non-surgical method that may do both with remarkable accuracy.
In a study of 118 patients with different types of brain cancer, researchers focused on the presence and abundance of different microRNAs in patients’ cerebrospinal fluid (CSF). MicroRNAs are short, single-stranded RNA molecules that help regulate gene expression. They have proven to be effective biomarkers for other conditions and can be accurately measured simply and inexpensively.
That utility appears to hold true for brain cancer as well. The scientists report that they found significantly increased levels of two specific types of miRNA in the CSF of patients with glioblastoma and brain metastasis of breast and lung cancer, compared to tumors in remission and a variety of non-neoplastic conditions.
Patients with brain metastases but no other pathologic conditions showed highly elevated levels of other types of miRNA, allowing researchers to discriminate between glioblastoma and metastatic brain tumors.
The scientists were able to achieve these diagnoses by measuring as few as seven miRNAs. Their accuracy rate was 91 to 99 percent.
In addition, they reported that disease activity and treatment response can be monitored by regularly profiling microRNA levels in the CSF of glioblastoma and non-small cell lung carcinoma patients.
“We are excited about the potential that this test has to ease the process of detecting and monitoring brain tumors,” said senior author Anna M. Krichevsky, PhD, of the Center of Neurologic Diseases at Brigham and Women’s Hospital in Boston. “The test needs to be further developed before it is used in a clinical setting, but I expect it could be particularly valuable for patients who are not surgical candidates due to the tumor’s size or location, or due to an underlying medical condition.”
(via fuckyeahmedicalstuff)
Attending: What is a bezoar?
Me: A stone-like mass taken from the stomach of a goat that is an antidote to most poisons.
Attending: Okay, how about a med student answer and not a Harry Potter one?
Me: Oh, it’s not the same thing?
Apparently, we don’t go to Hogwarts…
(via ermedicine)
Hitler as Seen by His Doctors, 1945 – 46
Military Intelligence Service Center, United States Army, European Theater
This is one of five known X-rays of Hitler’s head, part of his medical records compiled by American military intelligence after the German’s surrendered and declassified in 1958. The records also include doctor’s reports, diagrams of his teeth and nose and electrocardiograms.
(via zygoma)
(via zygoma)
HEILPFLANZEN - Sarah Illenberger
photo:Ragnar Schmuck
(via myanatomicallife)
Glow in the Dark Soldiers and a Civil War Mystery
At the Battle of Shiloh, some wounded soldiers waited days in the chilly rain for medical help. When soldiers usually waited that long, they were prone to deadly infections that doctors at the time couldn’t do anything about, much less understand the cause.
Some of them noticed that their wounds were glowing at night. Were they hallucinating?And those with glowing wounds had better survival rates. 140 years later someone figured out why.
Soil-dwelling worms like the one above are filled with bacteria that they use to eat and protect food they find in the soil. The luminescent bacteria inside the nematodes fight off other bacteria, and the worm and bacteria both get a tasty meal all to themselves.
The soil of the Shiloh battlefield was full of these worms and bacteria, and when they got into the soldier’s wounds they created a glowing, antiseptic worm bandage.
(via Mental Floss image via Nikon’s Small World)
Deadly Beauty
Ever since our conception, humans have fallen victim to infectious disease - microscopic, airbourne pathogens and parasites that infiltrate our bodies and turn them against us. Shown above, and described below, are 10 of the deadliest pathogens humankind has encountered throughout history. Some, like poliovirus, show how far we’ve come - while others, such as HIV, remind us how far we have still to go in the battle against nature’s smallest assassins.
The Bubonic Plague: Also called the Black Death due to the formation of necrotic tissue on living victims, the bubonic plague - most commonly caused by a small bacterium, Yersinia pestis - is estimated to have killed around 75 million people, including half the total population of Europe. Although controlled, the bubonic plague is still endemic today.
Poliomyelitis: One of the most dreaded childhood diseases of the 20th century, the causitive agent of polio, poliovirus, has caused 10,000 deaths since 1916, and permanent paralysis to thousands. Its presence in the population is substantially reduced in the modern day due to an effective polio vaccine and vaccination programme.
Smallpox: Marked in history as the pathogen of choice for the first-ever documented case of biological warfare, in which smallpox-infected blankets were thrown into enemy camps, smallpox and its two viral agents - variola major (pictured above) and variola minor - decimated the Native American population in the United States from 12 million to 235,000. It is also credited with destroying the Aztec civilisation when brought to South America by the conquistadors. WHO declared the official eradication of smallpox in 1979, although samples are still stored in laboratories for research.
Cholera: Caused by the bacterium Vibrio cholerae, cholera is perhaps best known for being one of the most rapidly fatal illnesses known - a healthy person may become hypotensive within an hour of symptoms onset, and will die within 2-3 if no treatment is provided. Cholera has killed approximately 12,000 people since 1991.
Spanish Influenza: An especially virulent strain of Influenza A virus, subtype H1N1, killed 50 to 100 million people in the years 1918 and 1919 alone. Many of its victims were healthy young adults, in stark contrast to the flu of today, which usually preys on the old and infirm. The extraordinary death toll is believed to have resulted from the extreme virulence of the virus and the severity of symptoms, believed to have been caused by cytokine storms.
Tuberculosis: Caused by various strains of mycobacteria, most commonly Mycobacterium tuberculosis, tuberculosis is a usually lethal and sadly common infectious disease that affects up to 80% of the population in some African and Asian countries.
Influenza: Commonly known as the flu, influenza is caused by a massive family of RNA-based viruses of the family orthomyxoviridae. It causes about 36,000 deaths per year.
Malaria: Malaria is a vector-bourne infectious disease caused by protozoan parasites of the genus Plasmodium, typically Plasmodium falciparum and Plasmodium vivax. It causes approximately 2.7 million deaths per year, a large percentage of them young children in sub-Saharan Africa. No vaccine has yet been created for malaria; drugs must be taken continuously to reduce the risk of infection.
AIDS: Acquired Immunodeficiency Syndrome (AIDS) is caused by HIV, the human immunodeficiency virus. Death results from specific damage to the immune system, leaving people susceptible to opportunistic infection in the late stages. Although treatments exist to decelerate the virus’ progression, there is no known cure, and 21 million have died of AIDS since 1981. HIV is usually passed by blood-to-blood transmission.
Ebola: Ebola is a potentially lethal hemorrhagic fever that has caused approximately 1,600 human deaths. It is a zoonotic disease caused by the ebola virus whose primary animal vector is thought to be the fruit bat. Mortality rates are generally very high, in the region of 80% – 90%, with the cause of death usually due to hypovolemic shock or organ failure.
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Images: Top left: Yersinia pestis. Top right: poliovirus. Second line, left: Variola major. Second line, center: Vibrio cholerae. Second line, right: Influenza A, subtype H1N1. Third line, left: Mycobacterium tuberuclosis. Third line, right: Influeza A. Bottom left: Plasmodium falciparum in red blood cells. Bottom center: HIV. Bottom right: Ebola virus.
(via fuckyeahmedicalstuff)
Board Integration.
Working the bits and pieces of five weeks worth of lectures onto one board as they relate to the thalamus.
The quilled paper anatomy art of Lisa Nilsson made it onto the cover of my new copy of Cell! I’ve posted her work previously here.
Awesome stuff.
(via fuckyeahmedicaldiagrams)
Hahah found this in “the medical post” newspaper!
I wonder if the famous Dr. Cranquis is like this… Too scared to ask :P
….When I gather enough courage maybe I’ll send it to him!
(via mymedspace)
The Human Brain.
When I hold the brain in my hand, I cannot help but wonder at the infinite layers of intricacies and complexities contained within it. Million upon millions of axon tracts firing impulses to every corner of the brain and conversely receiving signals from them, listening and communicating, analyzing and deciding, give us conscience, reason and bodily regulation. And to think that this powerful computational engine is simultaneously the same and different within all of us humbles me.